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Author

Xiong-Wei Zhu

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Review Open access Oct 2026

Mitochondrial dysfunction in Alzheimer's disease: mechanisms, pathogenic interplay, and therapeutic opportunities.

Alzheimer's disease (AD) remains a major cause of dementia, yet effective disease-modifying therapies are still limited. Although amyloid-β (Aβ) and tau pathology remain core features of AD pathogenesis, they do not fully explain how these pathological alterations drive progressive cellular dysfunction. Increasing evid...

Bao-Min Dou, Ji-Ming Chen, Hua-Ning Zhao et al. · 0 citations
Open access Aug 2026

Multi-regional transcriptomic analysis reveals early nociceptive and neuroinflammatory alterations in APP/PS1 mice

Background BackgroundAlzheimer's disease (AD) is characterized by progressive cognitive decline and neuropsychiatric symptoms, including chronic neuropathic pain. However, the molecular mechanisms linking pain sensitivity to early AD pathology remain poorly understood. Methods In the present study, 4- to 5-month-old AP...

Zhu-Tao Sheng, Fu Xu, Yu-Shan Yan et al. · 0 citations

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