Open access
Jul 2026
PDIA6 exacerbates hepatocellular carcinoma via enhancing proteasome-dependent degradation of AKAP12.
This study experimentally validated that PDIA6 promotes the proliferation and metastasis of HCC cells and uncovered the HCC-promoting mechanism of the PDIA6-AKAP12-Wnt signaling axis and highlights its great potential for the development of therapeutic targets in HCC.
Rucheng Yao, Yuhan Yin, Xiaosong Li et al.
· Cellular Oncology · 0 citations