Dissecting liver cancer stem cell heterogeneity via single-cell RNA sequencing and developing a stemness-based prognostic model.
BACKGROUND Liver cancer stem cells (CSCs) play a pivotal role in the initiation, progression, and recurrence of hepatocellular carcinoma (HCC), but their molecular and metabolic heterogeneity remains largely undefined. Characterizing subpopulations with enriched stemness features is crucial for understanding liver canc...