Mass-spectrometry Based Structural Proteomics in Characterizing Protein Higher Order Structure-Development and Applications in Neurodegeneration, Cancer, and Infectious Disease
Proteins carry out most biological functions, and their activities are governed by their higher-order structure (HOS), which arises from folding, assembly, and dynamic conformational rearrangements. These structures are not static but exist as ensembles of interconverting states that respond to environmental changes an...