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Author

Xing-Yu Guo

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Open access Aug 2026

Chronic Monobutyl Phthalate Exposure Promotes Anaplastic Thyroid Cancer Progression Through Inflammatory Signaling Dysregulation: Integrated Transcriptomic and Network Toxicology Analyses

Background/Objectives: Chronic exposure to endocrine-disrupting chemicals has been increasingly recognized as a potential contributor to cancer progression. Monobutyl phthalate (MBP), a major metabolite of dibutyl phthalate, is widely detected in human biological samples, yet its long-term impact on anaplastic thyroid...

Yu Deng, Songwei Tan, Jinlan Wei et al. · 0 citations
Review Open access 2026

Unveiling and harnessing: the tumor microenvironment in RAS/MAPK pathway-targeted therapy

Rational combination strategies are outlined that simultaneously target the RAS/MAPK axis and key TME vulnerabilities, such as immunotherapy combinations, CAF reprogramming, and ECM normalization, to overcome stromal-mediated resistance and achieve deeper, more sustained clinical responses.

Wen-Hao Ma, Xing-Yu Guo, Xiu-Ting Liu · 0 citations

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