Open access
Sep 2026
High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2
It is demonstrated that KLHDC2 can accommodate non-carboxylate scaffolds and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies.
Yao Chen, Rui-Chen Gao, Jia-Jia Li et al.
· Protein Science · 0 citations