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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xing-Lai Dai

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Open access Aug 2026

Integrative multi-omics reveals the POSTN+ CAF–APOE+ macrophage axis drives immunosuppression and progression in prostate cancer

An integrated single-cell atlas defines a critical POSTN+ CAF–APOE+ macrophage unit that is associated with a fibrotic and immunosuppressive TME in advanced prostate cancer, and suggested conserved enrichment and adverse prognostic impact of this stromal-immune axis across diverse tumor types, though tissue-specific context should be considered.

Yangzhou Liu, Ao-Chu Liu, Xing-Lai Dai et al. · 0 citations

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