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Open access Sep 2026

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

ABSTRACT Glioblastoma (GBM) is a lethal malignancy characterized by therapeutic resistance and recurrence, which are driven by dynamic cellular metabolic adaptation within the tumor microenvironment. However, the precise molecular metabolic mechanisms remain poorly understood. Here, we found that palmitic acid (PA) acc...

Zi-Jie Gao, Rong-Rong Zhao, Zhe-Yuan Chen et al. · 0 citations
Open access Sep 2026

Neutrophil extracellular traps delivering lactylated S100a9 aggravate neuronal cuproptosis by regulating Ttr/Commd1/Atp7b axis after traumatic brain injury

A novel pathway wherein NETs, via delivery of S100a9K26la, drive neuronal Ttr overexpression is identified, ultimately triggering neuronal cuproptosis and exacerbating secondary injury after TBI.

Jian-Ye Xu, Xu Zhang, Yang Liu et al. · 0 citations

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