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Author

Xing-Ding Zhang

2 papers indexed here

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Open access Sep 2026

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

A novel mechanistic insight is introduced into the pathogenesis of myeloma and bone deterioration and disruption of the ENO1–PTTG1 interaction is identified as a potential dual-targeting therapeutic strategy, demonstrating significant efficacy in curbing myeloma progression and osteolytic lesions.

Rui Liu, Ya-Zhu Huang, Z. Fang et al. · 0 citations
Open access Sep 2026

The NSDHL/c-Myc/PKM2 Axis Drives Glycolytic Reprogramming and Tumor Growth in Multiple Myeloma

Multiple myeloma (MM) remains largely incurable because of its complex biology and frequent disease relapse. Metabolic reprogramming is increasingly recognized as a critical contributor to MM progression. NAD (P)-dependent steroid dehydrogenase-like protein (NSDHL) has been highlighted as an unfavorable metabolism-rela...

Can Yue, Bei-Hui Huang, Lin Qi et al. · 0 citations

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