Autophagy represents an evolutionarily conserved intracellular degradation pathway. Aberrant activation or impaired autophagic flux contributes substantially to the pathogenesis and progression of numerous human diseases, such as tumors and neurological disorders. As the only cysteine proteases within the core autophag...
Dan Mu, Xiong Pei, Jia-Jie Feng et al.· Biochemical Pharmacology· 0 citations
A target-cell-oriented pharmacological map that integrates their autophagic targets, ferroptotic effects, disease contexts and relevant target-cell populations is constructed, thereby providing a rationale for developing ADF-based therapeutic strategies with defined indications, measurable pharmacodynamic biomarkers an...
Xiao Cui, Xinzhu Dong, Yang Li et al.· Pharmacological Research· 0 citations
This review systematically summarizes the molecular mechanisms underlying LMP initiation and execution, as well as the regulatory pathways of LDCD modalities, including apoptosis, necroptosis, ferroptosis, pyroptosis, immunogenic cell death, and autophagy-dependent death.
Yang Li, Jiajie Feng, Xinzhu Dong et al.· Biomarker Research· 1 citation
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