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Xin-Yue Zhang

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Open access Sep 2026

Targeting a cryptic Magnaporthe oryzae-specific pocket in succinate dehydrogenase to combat rice blast.

The global efficacy of succinate dehydrogenase inhibitors (SDHIs), a leading class of fungicides, is increasingly threatened by resistance, driven largely by their shared binding mode at the conserved ubiquinone-binding (Q) site. This challenge is particularly acute for rice blast, as no SDHI is registered for this dis...

Wei Zhang, Mian Wei, Bo-Yang Ye et al. · 0 citations
Aug 2026

SA-MPNN: A Sequence-Aware ThermoMPNN for Accurate Prediction of Mutational Effects on Protein Thermodynamic Stability.

Predicting the impact of single-point mutations on protein thermodynamic stability is crucial for protein engineering of therapeutic and industrial applications. By effectively capturing the three-dimensional structural information of proteins and the spatial physical environment of each residue, the inverse folding mo...

Xin-Yue Zhang, Xiang-Shan Zheng, Ze-Yuan Dong et al. · 0 citations

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