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Xin-Yue Wang

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Open access Sep 2026

Nucleoside-modified circRNA: Reduced immunogenicity and expansive applications beyond vaccines

mRNA drives the production of functional proteins to achieve therapeutic intervention, rendering it an attractive molecular platform for biomedical applications. In the 1990s, researchers established in vitro transcription (IVT) systems to produce linear mRNA encoding target proteins. Neverthe-less, unmodified mRNA exh...

Xin-Yue Wang, Sheng-Nan She, Chi Zhang et al. · Molecular Therapy: Nucleic A... · 0 citations

Open access Jul 2026

IVT-free, chemically synthesized protein-encoding RNA oligonucleotides for rapid production of personalized cancer vaccines

Significance Personalized mRNA cancer vaccines hold great therapeutic promise, yet their production depends on multistep in vitro transcription (IVT) that generates immunogenic dsRNA impurities and prolongs manufacturing to nearly three months, often missing the optimal therapeutic window. Here, we introduced a cap-ind...

Qian Pan, Chi Zhang, Xinyue Wang et al. · Proceedings of the National... · 0 citations