#protein folding
Sep 2026
Engineered Tumor-Homing Escherichia coli for Localized Hyaluronic Acid Degradation and Stromal Remodeling in Pancreatic Cancer.
Pancreatic ductal adenocarcinoma (PDAC) accumulates vast amounts of hyaluronic acid (HA), generating a rigid, high-pressure stroma that blocks drug delivery and infiltration. Although hyaluronidase (HAase) can dismantle this barrier, systemic administration of HAase depletes HA from healthy tissues and causes dose-limi...
Shuai Gao, Ting-Ting Liu, Chang-Hao Tian et al.
· Macromolecular Bioscience · 0 citations