It is demonstrated that KLHDC2 can accommodate non-carboxylate scaffolds and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies.
Yao Chen, Rui-Chen Gao, Jia-Jia Li et al.· Protein Science· 0 citations
Covalent drugs have attracted increasing attention in modern drug discovery because of their prolonged target engagement, enhanced pharmacological efficacy, and potential to address traditionally challenging protein targets. The rapid development of electrophilic warhead chemistry, chemical biology methods, and high-th...
Hai-Peng Yu, Xiao-Ran Wang, Xin-Yu Wang et al.· Chemistry· 0 citations
The molecular mechanisms, recent advances, and emerging applications of bioPROTAC technology are summarized, the current technical challenges are evaluated, potential strategies to address these limitations are discussed, and future directions that may facilitate its clinical translation are highlighted.
This review summarizes recent advancements in peptide-based PROTAC development, focusing on innovative delivery strategies and methods for enhancing efficiency, while also offering insights into future prospects aimed at optimizing therapeutic precision and efficacy.
Yuyang Li, Xiao-Wei Wang, Xinyu Wang et al.· The Journal of pharmacy and...· 1 citation
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