Xin-Yu Qi

Ensemble-Based Reconstruction and Prioritization of Binding Sites in Influenza A Nucleoprotein.

Influenza A nucleoprotein (NP) is essential for viral RNA binding, ribonucleoprotein assembly, and NP oligomerization, making it an attractive antiviral target; however, static structures incompletely capture the conformational variability governing pocket formation and accessibility. Here, 17,178 pockets detected acro...