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Xin-Yu Chen

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Review Open access Sep 2026

Mechanisms of immune resistance in microsatellite-stable colorectal cancer

Microsatellite-stable (MSS) colorectal cancer (CRC) accounts for approximately 85% of all CRC cases and exhibits limited responsiveness to immune checkpoint inhibitors (ICIs), representing a major challenge in current cancer immunotherapy. At the tumor-cell intrinsic level, low tumor mutational burden (TMB), impaired n...

Dong-Guang Niu, Peng Liu, Xin-Yu Chen et al. · 0 citations

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