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Sep 2026

Cargo crosslinking nucleates AP-1 lattice formation.

Vesicle trafficking is critical for proper distribution of proteins and lipids within eukaryotic cells. This process relies on the selective incorporation of cargo into transport carriers by coat systems, including adaptor-clathrin complexes. While the molecular basis of cargo recognition is well established, the exten...

Hua-Qing Deng, Guo-Wen Jia, Qin Yang et al. · 0 citations
Open access Jul 2026

HUWE1 targets mitochondria via RMC1 to promote neurodevelopment.

An AMBRA1-RMC1-HUWE1 signaling axis that directs HUWE1-mediated ubiquitination to mitochondria to regulate neural development is identified and mitochondrial quality-control enhancement as a potential therapeutic strategy is suggested.

Jia-Min Yi, Qin Yang, Chun Zhou et al. · 1 citation

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