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Findings highlight isobavachalcone (IBC) as a potential drug candidate that promotes PD-L1 degradation and demonstrate the therapeutic potential of targeting the OTUB1-PD-L1 axis to improve immune checkpoint therapy.
Invasive fungal infections pose a serious global health threat. Although core cellular processes are broadly conserved across fungi, only a small fraction of known species cause severe human disease, suggesting that pathogenicity may depend in part on pathogen-specific regulators. However, such elements remain poorly u...
A multi-layer molecular framework of human acute hypoxic stress is defined, linking vascular regulation, inflammation, coagulation, metabolic remodeling, tissue origin, and biomarker prioritization in hypoxia-associated systemic diseases.
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