Xin-Yi Zhao

Charge-altering histone mutations reprogram electrostatic coupling from single nucleosomes to higher-order chromatin structures.

It is shown that charge-altering mutations are enriched among recurrent high-frequency mutations and exhibit stronger predicted destabilizing effects on nucleosome-associated interactions than charge-neutral variants, and higher-order nucleosome assemblies show that charge-altering mutations can modulate inter-nucleoso...