Author

Xin-Yi Zhang

2 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Aug 2026

A mechanism-annotated benchmark reveals limited fidelity to drug-response signatures in single-cell perturbation models

Single-cell drug perturbation models are increasingly used to predict how compounds remodel cellular states, but they are still largely assessed by expression reconstruction. Whether high expression similarity reflects preservation of drug-response signatures remains unclear. Here we present scDrugPerturb-Bench, a mech...

Le-Hang Li, Shaoming Duan, Xin-Yu Zha et al. · bioRxiv · 0 citations

Open access Sep 2026

Spatial isoform sequencing at single-cell resolution reveals cell-type-specific spatial isoform variability in multiple brain cell types

Spatial long-read technologies are increasingly common but usually lack single-cell resolution. This leaves unanswered whether spatially variable isoforms reflect variability within one cell type or differences in region-specific cell-type composition. Here, we developed Spl-ISO-Seq2 (500-nm resolution) and accompanyin...

Lieke Michielsen, Andrey D. Prjibelski, Careen Foord et al. · Nature Methods · 0 citations