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Author

Xin-Yi Wang

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Open access Sep 2026

CDK1-mediated phosphorylation of APE1 drives synthetic lethality, p53-dependent metastasis, and immune sensitization in NSCLC

Cyclin-dependent kinase 1 (CDK1), a serine/threonine kinase essential for cell cycle progression, also plays critical roles in DNA damage response, gene expression regulation, and therapeutic resistance. In this study, we identify a previously unrecognized regulatory link between CDK1 and apurinic/apyrimidinic endonu...

Jian-Lin Wang, Jiang Li, Jia Peng et al. · 0 citations
Review Sep 2026

BRN2 in Lineage Plasticity: A Prostate Cancer-Focused Perspective.

This review examines how BRN2 connects developmental neurogenesis to therapy-induced tumor reprogramming and integrates insights from neurodevelopment and direct lineage reprogramming to describe how BRN2 maintains stem-like and neuroendocrine transcriptional states.

Fatemeh Seilani, Jia Peng, Meng Wu et al. · 0 citations

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