Antitumor EF24 analogue-integrated platinum (IV) prodrugs induce autophagy-mediated immunogenic cell death and PD-L1 downregulation in colorectal cancer.
The oxaliplatin-based therapy regimens for colorectal cancer (CRC) presents a significant challenge to clinical application owing to the severe side effects and drug resistance. To enhance the selectivity and therapeutic efficacy of oxaliplatin, we designed and synthesized a series of platinum (IV) prodrugs by conjugat...