Author

Xin-Yi Tan

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Sep 2026

Mesenchymal Tumors Feature a Spatially Defined Glial-Tip Cell Niche Around the Tumor Boundary in Microsatellite-Stable Colorectal Cancer.

Colorectal cancers (CRC) with microsatellite stability (MSS) and instability (MSI) differ in tumor microenvironment (TME) composition and clinical treatment and outcomes. While MSI CRC is considered to be sensitive to immune checkpoint blockade therapy, MSS tumors are largely resistant. Characterizing the spatial TME d...

Dong Zhang, Hui-Fang Chen, Liang Gu et al. · Cancer Research · 0 citations

Open access Aug 2026

H3.3 chaperone Hira primes the effector program and function of regulatory T cells

It is shown that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program, revealing a previously unreported epigenetic mechanism critical for Treg effector differentiation and function.

Xiang-Xiang Cao, Meng-Jie Lv, Zhi-Han Lv et al. · Science Advances · 0 citations