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Xinyi Lv

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Open access Sep 2026

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2 +–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

ABSTRACT Morphine‐associated contextual reward learning promotes maladaptive drug–context associations during opioid exposure. Hederagenin (HE), a bioactive compound from traditional Chinese medicine, has neuroprotective potential, but its role in contextual reward learning remains unclear. Here, we investigated the ef...

Hong-Yan Jiang, Zi-Ting Zhou, Nan-Nan Xue et al. · 0 citations
Jul 2026

Decoding Anxiety: Plasma Lipids and Proteins as Causal Agents.

This work leveraged two-sample Mendelian randomization to systematically evaluate the causal effects of 179 plasma lipid species and 4,907 plasma proteins on anxiety disorders, using two large-scale independent GWAS datasets for replication and identified three lipids with robust causal effects.

Jiahui He, Ze-Han Zhang, Yanan Wang et al. · 0 citations

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