Xin-Ye Ouyang

Nucleotide metabolic reprogramming: a “double-edged sword” in obesity-related inflammation—from metabolic adaptation to pathological imbalance

Obesity has become a serious global public health challenge, characterized by chronic, sterile, low-grade inflammation with excessive NLRP3 inflammasome activation; however, the mechanism underlying the reduced activation threshold remains unclear. A recent study by Liu et al. demonstrated that obesity induces the phos...