Author

Xin-Yao Feng

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Open access Oct 2026

Integrating genome-wide association study and haplotype-resolved epigenomes reveals complex parent-of-origin effects in pigs

Parent-of-origin effects (POEs) violate the assumption of additive genetic models by allowing allelic effects to depend on parental origin, yet their mechanistic basis remains incompletely understood. Here, we combine genome-wide POE mapping in an F2 Eurasian pig population with haplotype-resolved transc...

L. Tao, Li-Gang Wang, Jian-Bo Li et al. · BMC Genomics · 0 citations

Review Open access Aug 2026

RNF213 in Panvascular Disease: A Molecular Hub Linking Genetic Susceptibility to Systemic Vasculopathy

This review synthesizes current evidence elucidating RNF213′s multifaceted roles in vascular homeostasis, spanning its functions as an E3 ubiquitin ligase, mechanosensor, and immune modulator and outlines unresolved questions regarding context-dependent effects of RNF213 variants and organ-specific regulatory mechanism...

Zhenghaonan Qiu, Guicheng Kuang, H. Ji et al. · Biomedicines · 0 citations