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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Xin Yang

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Review Open access Oct 2026

Tumor microenvironment-driven therapeutic resistance in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most treatment-refractory malignancies, with limited and often transient benefit from chemotherapy, targeted therapy, immunotherapy, and radiotherapy. Therapeutic resistance is increasingly recognized as an ecosystem-level process arising from reciprocal intera...

Hong-Jiao Li, Jia-Ning Cui, Xin Yang et al. · 0 citations
Jul 2026

RBCK1 promotes chemotherapy resistance in bladder carcinoma by targeting HLTF.

Integrated analysis of public transcriptomic datasets identify an RBCK1-HLTF-JAK2/STAT3 regulatory axis that promotes cisplatin resistance in bladder cancer cells, and xenograft validation further supports the role of RBCK1 depletion in enhancing cisplatin response in vivo.

Xin Yang, Ze-Xian Ding, Peng-Wang Ya et al. · 0 citations

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