A novel γ-chain Tyr306Asn missense mutation causes congenital dysfibrinogenemia.
BACKGROUND Congenital dysfibrinogenemia is an inherited disorder caused by fibrinogen gene defects, leading to structural and functional abnormalities of the protein. We identified a novel heterozygous γTyr306Asn mutation in a 26-year-old woman and aimed to elucidate its pathogenic mechanism. METHOD The study used co...