Xin-Xin Shi

From marrow memory to adverse ventricular remodeling: trained immunity after myocardial infarction

Myocardial infarction [MI] triggers a sterile inflammatory response that is essential for necrotic-tissue clearance and scar formation and should normally subside as repair progresses. In a subset of patients, however, persistent myeloid activation accompanies progressive fibrosis, ventricular dilatation, and adverse r...