Aug 2026
Cryo-EM structure of the WDR11-FAM91A1-C17orf75 complex involved in retrograde trafficking.
Functional analyses demonstrate that C17orf75 is indispensable for the proper intracellular localization of the acidic-cluster-containing cargo proteins CI-MPR, KIAA0319L, and VAMP4 and establish C17orf75 as an integral component of the WFC complex in endosome-to-TGN trafficking.
Yifan Zhang, Zhi-Min Liu, Zi-Rong Chen et al.
· Structure · 1 citation