Author

Xin Ma

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Open access Oct 2026

The KLF4–SLC25A4 mitochondrial axis regulates ferroptotic vulnerability and sunitinib sensitivity in clear cell renal cell carcinoma

Sunitinib resistance remains a major therapeutic challenge in clear cell renal cell carcinoma (ccRCC). Through integrated transcriptomic profiling and mitochondrial gene screening, we identified SLC25A4 as a ferroptosis-associated tumor suppressor. SLC25A4 expression was significantly downregulated in ccRCC tissues a...

Shuo Tian, Hai-Rui Chen, Wen-Lei Zhao et al. · Scientific Reports · 0 citations

Review Open access Sep 2026

Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics

The von Hippel-Lindau (VHL) gene encodes the core substrate-recognition subunit of the Cullin2-RING E3 ubiquitin ligase complex, regulating cellular oxygen sensing and proteostasis. While targeting the canonical VHL-hypoxia-inducible factor (HIF) axis (e.g. belzutifan) has improved advanced clear cell renal cell carcin...

Rui-Yi Deng, Bo-Yuan Wang, M. Zou et al. · Biomarker Research · 0 citations

Jul 2026

NME3 promotes clear cell renal cell carcinoma progression and modulates TKI response through MFN1/2-dependent mitochondrial fusion and mitophagy suppression

It is found that NME3 is significantly upregulated in ccRCC and correlates with poor survival and serves as an independent prognostic factor, highlighting a potential link between mitochondrial remodeling and therapeutic response.

Sen-Ming Cao, Xin-Ran Chen, Chi Zhang et al. · Oncogene · 0 citations