Prostate cancer is an immunologically cold tumor with a limited response to immune checkpoint blockade. Although tertiary lymphoid structures (TLSs) are associated with favorable immunotherapeutic outcomes in various malignancies, the tumor-intrinsic mechanisms governing their formation in prostate cancer remain poorly...
Yi-Ni Zhu, Yan Liu, Zi-Yu Zeng et al.· Cancer Letters· 0 citations
EPHA3 showed the largest fold change among the most significant differentially expressed genes in LNCaP-TR-BoM compared with the parental line, demonstrating the potential utility of the LNCaP-TR-BoM cell line as a discovery system for genes relevant to driving AR-intermediate bone-metastatic prostate cancer.
Using standardized oracle inputs and Cohen’s κ, it is found that, within the ranges tested, the major paradigms achieved comparable accuracy, and the field’s near-term gains lie in strengthening infrastructure—prioritizing tool accessibility, standardized evaluation, and robustness to pipeline variation.
Oliver Wardhana, Zi-Yu Zeng, Xin Lu· bioRxiv· 0 citations
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