Author

Xin Liu

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Open access Oct 2026

Machine learning models integrating 2D and 3D intratumoral heterogeneity features from multi-sequence MRI: accurate prediction of perineural invasion in pancreatic ductal adenocarcinoma

Perineural invasion (PNI) occurs in the majority of pancreatic ductal adenocarcinoma (PDAC) cases and is strongly associated with local recurrence, neuropathic pain, and poor survival, yet no reliable method exists for its preoperative identification. Here, we developed and externally validated a multi-sequence MRI...

Zhi-Qiang Ouyang, Zheng-Rui Song, Zhi-Lin Li et al. · Frontiers in Artificial Inte... · 0 citations

Open access Sep 2026

A Lynch Syndrome Family With Germline MLH1 c.931A>G Showing Preserved Tumor MMR Immunostaining but MSI‐H Status: A Case Report

This case highlights that preserved tumor MMR immunostaining does not exclude Lynch syndrome when clinical suspicion is high and Concurrent MSI and MMR immunohistochemistry, interpreted together with tumor sequencing and germline testing, may improve diagnosis, treatment selection, and familial risk assessment.

Jing-Jing Cai, Zhuo-Ying Li, Ting-Ting Han et al. · Clinical Case Reports · 0 citations

Aug 2026

Integrated bulk, single-cell and spatial transcriptomic analyses identify KIFC1 as a driver of malignant progression in lung adenocarcinoma

Computational analyses suggest a potential relationship between KIFC1-associated malignant states and tumor microenvironmental signaling, supporting its value as a prognostic biomarker and potential therapeutic target.

Linghan Tian, Yuan-Biao Wang, Li Huang et al. · Molecular Biology Reports · 0 citations