Open access
Sep 2026
Fibroblast-associated TPM2 links cell-matrix remodeling to EMT-Notch signaling and gemcitabine resistance in intrahepatic cholangiocarcinoma
ABSTRACT Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver malignancy with heterogeneous responses to gemcitabine-based chemotherapy. The cellular and microenvironmental programs associated with the gemcitabine response remain incompletely understood. This study aimed to identify tumor microenviro...
Ying-Jiao Zhu, Zhi-Bin Qiao, Zhu-Hong Chen et al.
· Cancer Biology & Therapy · 0 citations