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Xin-Kui Zhou

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Open access Sep 2026

Greb1l is essential for pronephric tubule morphogenesis in zebrafish by maintaining cell homeostasis via MAPK signaling

Mutations in the human GREB1L (growth regulation by estrogen in breast cancer 1-like) gene are associated with congenital anomalies of the kidneys and urinary tracts (CAKUT). However, its precise function and molecular mechanisms remain poorly understood. This study aimed to explore the role of Greb1l deficiency...

Ji-Tong Li, Jie-Ru Wei, Yao-Dong Zhang et al. · 0 citations
Sep 2026

Tmlhe deficiency induces neurodevelopmental dysfunction and synaptic excitatory/inhibitory imbalance linked to autism-like phenotypes in zebrafish.

It is demonstrated that tmlhe deficiency disrupts carnitine biosynthesis, impairing energy and glycerophospholipid metabolism, which is critical for early neurogenesis, which may lead to impaired neural development and a synaptic E/I imbalance, ultimately causing ASD-like phenotypes.

Ji-Tong Li, Xiao-Tong Zhao, Jie-Ru Wei et al. · 0 citations
Review Open access Aug 2026

Advances in organoids for personalized medicine: from technological development to clinical application

Current progress and future directions in organoid research are delineated, furnishing a theoretical foundation and guiding future investigations towards enhancing personalized treatment paradigms.

Xin-Kui Zhou, Xing-Xue Yan, Zheng-Yang Zhang et al. · 0 citations

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