Mutations in the human
GREB1L
(growth regulation by estrogen in breast cancer 1-like) gene are associated with congenital anomalies of the kidneys and urinary tracts (CAKUT). However, its precise function and molecular mechanisms remain poorly understood. This study aimed to explore the role of Greb1l deficiency...
It is demonstrated that tmlhe deficiency disrupts carnitine biosynthesis, impairing energy and glycerophospholipid metabolism, which is critical for early neurogenesis, which may lead to impaired neural development and a synaptic E/I imbalance, ultimately causing ASD-like phenotypes.
Ji-Tong Li, Xiao-Tong Zhao, Jie-Ru Wei et al.· Progress in Neuro-psychophar...· 0 citations
Current progress and future directions in organoid research are delineated, furnishing a theoretical foundation and guiding future investigations towards enhancing personalized treatment paradigms.
Xin-Kui Zhou, Xing-Xue Yan, Zheng-Yang Zhang et al.· Frontiers in Cell and Develo...· 0 citations
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