Xinhui Chen

USP18/DDX5 axis ameliorates mitochondrial morphofunctional damage via OPA1 to inhibit neuronal apoptosis after traumatic brain injury.

BACKGROUND Traumatic brain injury (TBI) is a leading cause of mortality and morbidity and a major contributor to loss of working capacity in young adults. Current therapeutic options for TBI remain limited. This study aimed to assess the potential role and therapeutic value of ubiquitin-specific protease 18 (USP18) in...

Multi-omics Insights into Oxidative Stress-related Genes and Neurodegenerative Diseases: From Epigenetic Regulation to Pathogenic Pathways

Rare Heterozygous Loss-of-Function Variants in MCOLN1 Identified in Two Sporadic Patients with α-Synucleinopathies.

It is demonstrated that both heterozygous MCOLN1 variants impair TRPML1 function in vitro, identifying MCOLN1 as a candidate gene for α-synucleinopathies that warrants further investigation in larger cohorts.