Xin-Hua Shao

Single-cell transcriptomic analysis reveals endothelial mitochondrial dysfunction and synaptic impairment underlying arsenic-induced hippocampal neurotoxicity in mice.

Although arsenic (As) exposure is a well- established neurotoxicant, the cellular heterogeneity and underlying molecular mechanisms remain incompletely understood. In the present study, scRNA-seq was performed on the hippocampi of mice exposed to 50 mg/L sodium arsenite (NaAsO₂) via drinking water for 12-weeks. Nine ce...