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Author

Xin Hu

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Open access Oct 2026

Construction of a GCSCs-Related Prognostic Risk Model Based on Transcriptomic Data

Gastric Cancer Stem Cells (GCSCs) contribute to tumor progression and treatment resistance, but their heterogeneity and tumor microenvironment interactions remain unclear. We analyzed GSE163558 single-cell RNA-sequencing data from 10 gastric cancer samples and integrated GCSC-related genes with The Cancer Genome Atlas...

Xin Hu, Shi-Qi Fan, Nai-Qiang Liu et al. · 0 citations
Open access Sep 2026

The DCBLD2 super-enhancer drives colorectal cancer progression through FOSL2/JUND-mediated activation of the CD146/AKT/TNFRSF6B pathway

This study uncovers a previously undescribed DCBLD2-centered regulatory cascade that promotes colorectal cancer initiation and progression and represents promising prognostic biomarkers and actionable therapeutic targets for colorectal cancer.

Tong Wu, Lan Shao, Xin Hu et al. · 0 citations
Open access Jul 2026

Deciphering the Leading-Edge Spatiotemporal Microenvironment of Hepatocellular Carcinoma for Targeted Drug Discovery Using SpaPred

SpaPred provides a hypothesis-generating framework for investigating spatial heterogeneity and candidate therapeutic vulnerabilities in HCC and prioritized Oxaliplatin, Belinostat, and Temsirolimus as candidate compounds associated with LE-related transcriptional programs.

Shi-Bo Zhang, Ziqiao Li, Kexin Yu et al. · 0 citations

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