Author

Xin Guo

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Open access Sep 2026

Monoclonal antibody 1B9 against the African swine fever virus viroporin pB169L: molecular characterization and epitope mapping

The African swine fever virus (ASFV) viroporin pB169L is a conserved membrane protein, but well-defined reagents for its detection and molecular characterization remain limited. A soluble recombinant antigen comprising the non-transmembrane regions of pB169L was used to generate a mouse monoclonal antibody (...

Zhi-Ying Cui, Jia-Ning Feng, Miao-Miao Ye et al. · Frontiers in Microbiology · 0 citations

Open access Sep 2026

A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus

ABSTRACT Getah virus (GETV) is an emerging arthropod-borne zoonotic alphavirus that poses a growing threat to animal and public health, yet its virulence determinants remain poorly understood. Here, we report the first identification of a natural GETV variant isolated from the brain of diseased piglets. This variant ha...

Zhao-Ying Xiang, Gan-Bo Li, Jia-Yi Wang et al. · Virulence · 0 citations

Open access Sep 2026

African swine fever virus impairs porcine alveolar macrophages bactericidal function by disrupting lysosomal acidification and cathepsin activity

African swine fever virus (ASFV) is a devastating pathogen that poses a severe threat to the global swine industry. ASFV primarily targets the porcine monocyte-macrophage system, which is crucial for defending against bacterial infections via phagocytosis and subsequent intracellular degradation. Clinically, ASFV infec...

Zhen Xu, Feng-Yang Shi, Zhi-Yong Xiang et al. · PLoS Pathogens · 0 citations