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Review Open access Oct 2026

Bioactive small-molecule gas delivery for enhanced bone regeneration: modulation of cellular signaling and remodeling of the regenerative microenvironment

Complex bone defects are characterized not only by structural loss but also by persistent inflammation, insufficient vascularization, oxidative stress, impaired cell recruitment, and disrupted bone remodeling, which collectively limit endogenous repair. Bioactive small-molecule gases have emerged as versatile regulator...

Zhou Zhong, Biao Cao, Xin Duan · 0 citations

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