Author

Xin-Chen Bao

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Open access Sep 2026

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration.

Alzheimer's disease and primary tauopathies are marked by changes in adaptive immunity, with increased brain CD8+ T cells correlating with tau pathology severity. However, how peripheral T cells get primed to enter the brain and contribute to tau-mediated neurodegeneration remains unclear. In different disease conditio...

Hao Hu, P. Lin, Carisa Zeng et al. · Nature Neuroscience · 0 citations

Open access Sep 2026

The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy

Objective T cells are increased in the brain in Alzheimer’s disease (AD) and primary tauopathies where they correlate with tau pathology. In mouse models, T cells exacerbate tau-related neuroinflammation and neurodegeneration, and depletion of T cells is neuroprotective. Here, we investigate whether the multiple sclero...

M. Rudman, Alexandra Litvinchuk, Cathryn Smith et al. · bioRxiv · 0 citations