Author

Xin Chen

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Open access Oct 2026

Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells

Tumor metastasis is the leading cause of death for more than 90% of cancer patients, with colorectal cancer (CRC) mainly spreading to the liver. The colon and liver possess distinct nutritional microenvironments, yet how these differences shape the tumor immune landscape remains unclear. Using single-cell analysis of a...

Wang-Zheng Wang, Bai-Da Kong, Chang-Yuan Huang et al. · Signal Transduction and Targ... · 0 citations

Review Open access 2026

Navigating the aging brain: The interplay between brain malignancy and the aging microenvironment

This review deconstructs the existing knowledge at the intersection of cancer neuroscience and aging biology, and proposes therapeutic strategies that target convergent aging mechanisms through senolysis, metabolic reprogramming, and neurotransmitter modulation may simultaneously achieve tumor control and preserve cogn...

Qian-Quan Li, Jun-Yan Zhang, Jian Luo et al. · Ageing and Cancer Research &... · 0 citations