Open access
Aug 2026
DLST drives lung adenocarcinoma progression by modulating cuproptosis-related copper homeostasis and apoptosis via an EP300-dependent mechanism
Highlights • DLST is significantly upregulated in lung adenocarcinoma (LUAD) and correlates with advanced clinical stage and poor prognosis, promoting tumor growth by increasing intracellular copper levels and modulating cuproptosis-related proteins (HSP70, SLC31A1).• Mechanistically, the EP300–DLST–DLD axis is identif...
Tonghai Huang, Lin Chen, Zeyao Li et al.
· Translational Oncology · 0 citations