Open access
Sep 2026
HDX-MS-Guided computational modeling for rapid and accurate antibody-antigen interface mapping
ABSTRACT Accurate mapping of paratopes and epitopes at antibody-antigen (Ab-Ag) interfaces is essential for the rational design of therapeutic antibodies in early drug development. Traditional methods for determining high-resolution Ab-Ag complex structures, such as X-ray crystallography and cryo-electron microscopy, a...
William P. McMahon, Han-Zhi Zhang, Xiu-Ling Li et al.
· mAbs · 0 citations