Open access
Aug 2026
Live-attenuated Toxoplasma gondii RHΔddx6 mutant establishes comprehensive immunity against acute, chronic, and congenital toxoplasmosis
ABSTRACT Toxoplasma gondii is an obligate intracellular parasite causing severe disease in immunocompromised individuals and congenitally infected infants. Despite decades of research, no licensed human vaccine exists. This study evaluates a novel live-attenuated vaccine candidate based on depletion of DDX6, a conserve...
Zhen-Ke Yang, Jinghui Wang, Junru Wu et al.
· Virulence · 0 citations