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Author

Xiaoting Niu

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Open access Jul 2026

Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling

A liver-preferential KEAP1 degrader was developed to mitigate DILI by dual activation of the NRF2 and PGAM5 pathways, offering a promising therapeutic agent and more in-depth mechanistic insights into KEAP1-targeted degradation for enhanced anti-DILI therapy.

Yanyan Deng, Leizhi Xu, Xiaoting Niu et al. · 0 citations

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