Author

Xiaole Han

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Open access Jul 2026

A structural accessibility principle for LbuCas13a activation by noncontiguous DNA

It is shown that activation occurs only when overhang positioning creates an accessible protein–DNA interface, and a structural accessibility principle for LbuCas13a activation by noncontiguous DNA is defined.

Wei-Tao Wang, Yu-Han Chen, Ziyun Li et al. · Nucleic Acids Research · 0 citations