Xiaohong Lyu

T-Cell Exhaustion and Senescence in Cancer: Regulatory Circuits and Therapeutic State Engineering.

In cancer, T-cell state strongly influences antitumor immunity and response to immunotherapy. High-parameter cytometry, single-cell transcriptomics, and multiomic profiling now resolve lineage identity, differentiation history, clonality, metabolic fitness, and tissue adaptation in parallel. These studies place naïve,...