Radiotherapy is often limited by tumor-intrinsic DNA repair and an immunosuppressive microenvironment, both of which are reinforced by lactate accumulation. Here, we develop a CXCR4-engineered enucleated hepatocyte cytoplast platform decorated with Au-Pt Janus nanorobots (AP/LCCXCR4) to deplete intratumoral lactate and...
Yue-Yue Fan, Jia-Min Ye, Yuan-Fang Chen et al.· Cell Reports Medicine· 0 citations
This review systematically explores the dual roles of tumor‐associated microbiota‐both promoting and suppressing malignancy‐and highlights the transformative potential of engineered bacterial systems in cancer treatment, and discusses innovative strategies in which bacteria are harnessed to remodel the immunosuppressiv...
A pathology-driven and engineering-guided perspective for understanding the rational design and future development of exosome-based therapeutics for CNS disorders is provided.