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Xiao-Yu Zhao

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Sep 2026

Pathway-Dependent Energetics of SLC15A4–TASL Engagement: Single-Protomer Switching and Dimer-Interface Remodeling

Membrane-embedded signalosome assembly is co-gated by conformational selection, oligomeric interfaces, and the lipid microenvironment, yet short-lived, tightly coupled intermediate states are hard to infer from static structures. SLC15A4 recruits TASL to support IRF5 signaling, but available structures largely captur...

Xiao-Yu Zhao, Dan-Yang Xiong, Feng Gao et al. · 0 citations

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